Treatment for Melasma
Monday, August 16th, 2010Melasma is defined as the patchy darkening of skin in sun exposed areas, typically on the face. The cheekbones, cheeks, and forehead are most commonly affected. 90% of cases occur in women and it is thought to be related to hormonal activity, especially progesterone, but the exact mechanism is not known. Melasma is most common in medium-pigment skin, such as in Asians and Hispanics.
The patches of increased pigment begin very gradually but can become quite noticeable and bothersome. The “mask of pregnancy” is a manifestation of melasma. Starting oral contraceptives can also bring on melasma.
Melasma is challenging to treat. First and most importantly, the stimulus for the melasma must be addressed. Strict sun avoidance is a requirement. Even visible light can stimulate melasma lesions, so sunblocks are not adequate by themselves, since they only screen out UV light. Second, if oral contraceptives are being used, alternatives should be explored.
The mainstay of melasma treatment is topical. Hydroquinone is the foremost bleaching cream that inhibits the enzyme in the skin that makes melanin. There are alternative bleaching agents, such as kojic acid, but hydroquinone is the best-studied and gives the best results. Retinoic acid is also helpful by speeding up skin cell turnover. When hydroquinone, retinoic acid and a topical steroid are used as a triple combination together, the best results occur. Even so, results take months to achieve, and sun avoidance must be maintained .
Lasers and chemical peels are an option to speed the improvement of melasma. Chemical peels remove the overlying layers of pigmented epidermis and so are helpful. However, they will not penetrate into the deeper layers of skin pigment. Fractionated laser, such as Fraxel, can be helpful but there is a small risk of reactive hyperpigmentation. Q-switched Nd:YAG is also helpful and works by a different mechanism, similar to laser tattoo removal. However, all these methods are adjuncts to topical treatment and will not achieve good results without pretreatment with topicals.